The United states Startup Ecosystem

Overview

The United States boasts the largest and most dynamic startup ecosystem in the world, with major hubs like Silicon Valley, New York City, and Boston. This ecosystem is characterized by a strong venture capital presence and a supportive culture for innovation and entrepreneurship. The U.S. continues to lead globally in technological innovation and startup activity, contributing significantly to economic growth and job creation.

Size of the Market

As of 2024, the U.S. is home to approximately 77,927 startups. The startup ecosystem is supported by substantial venture capital investments, which totaled around $162.6 billion in 2022. This robust financial backing highlights the confidence investors have in the U.S. startup market, ensuring ample funding for innovation and growth.

Key Strengths

Key strengths of the U.S. market include a highly skilled workforce, advanced technological infrastructure, and a culture that encourages risk-taking and entrepreneurship. The presence of major tech companies like Google, Apple, and Facebook fosters a collaborative environment and provides ample opportunities for startups. Additionally, the U.S. government offers support through various grants and tax incentives, such as the Small Business Innovation Research (SBIR) program.

Major Hubs

Silicon Valley remains the epicenter of innovation, driving advancements in AI, biotechnology, fintech, and clean energy. New York City excels in finance and media, while Boston is strong in biotechnology and education-driven startups. These regions are crucial to the U.S. startup ecosystem, offering a wealth of resources, talent, and opportunities.

Emerging Hubs

Cities like Austin, Denver, and Seattle are emerging as significant tech hubs. These cities provide a favorable business climate, quality of life, and are becoming attractive locations for startups and talent. The rise of remote work has further expanded opportunities for startups to access talent from various regions, contributing to the growth of these emerging hubs.

Support Systems

The U.S. startup market benefits from a comprehensive support system of accelerators, incubators, and co-working spaces. Programs like Techstars and Y Combinator have been instrumental in nurturing early-stage startups, providing mentorship, resources, and funding. These support systems help startups at various stages of their journey to scale and succeed.

Challenges

Despite its strengths, the U.S. startup ecosystem faces challenges such as high costs of living, regulatory hurdles, and intense competition for talent. These challenges can create barriers for new startups and require strategic navigation to ensure long-term success.

Opportunities and Future Outlook

The U.S. startup market features a diverse customer base and a culture that encourages innovation and entrepreneurship. The rise of remote work has expanded opportunities, allowing startups to access talent from various regions. The future outlook remains positive with continuous growth and innovation, driven by emerging technologies such as blockchain, quantum computing, and green energy.

Resilience and Adaptability

The U.S. startup ecosystem is characterized by its resilience and adaptability. Despite challenges, the ecosystem continues to evolve, driven by a strong culture of entrepreneurship and technological advancements. This ensures the U.S. remains at the forefront of global innovation, contributing significantly to economic growth and job creation.

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We found 8,887 VC firms in the United states investing in Medical Devices on Angels Partners

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Rich Levandov
Investing in Software (Web Marketplace Saas..) &b...
 Cambridge Massachuset..., U.S.A.
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Previous Investments
  • AristaMD: $11000000 (Early stage VC)
  • Node: $10800000 (Early stage VC)
  • Talla: $8300000 (Early stage VC)
  • Averon: $8300000 (Early stage VC)
  • Smyte: $4000000 (Early stage VC)
  • Seva: $2400000 (Seed Round)
  • NanoNets: (Seed Round)
  • ScoreStream: (Later stage VC)
  • Jnana: $50000000 (Early stage VC)
  • Avelas Biosciences: $20000000 (Later stage VC)
  • Fortis Therapeutics: $18000000 (Early stage VC)

Rich Levandov

Cambridge Massachusetts - Massachusetts - San Francisco (CA) San Diego, California, U.S.A.

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • BioTech • A.I. (& Big Data) • Medical Devices (& Hospital Services) • DeepTech • Healthcare (& Wellness) • Investment Management • Life Science • Pharmaceutical (& Medicine)

Description

Partner at @avalon-ventures; Co-founder @phoenix-technologies (PTEC); Vice President at America Online

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Lainy Painter
Investing in Software (Web Marketplace Saas..) &b...
 San Francisco Bay Are..., U.S.A.
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Previous Investments
  • Bandana: $4000000 (Seed)
  • Sensible: $7000000 (Seed)
  • Entera: $32000000 (Series A)
  • Entera: $8000000 (Seed)
  • Plume: $14000000 (Series A)
  • BounceX: $37000000 (Series B)
  • Prodigy: $5400000 (Seed)

Lainy Painter

San Francisco Bay Area - California, U.S.A.

Investing In

Software (Web Marketplace Saas..) • PropTech • Education • Businesses Solutions • HealthTech (& Fitness) • Medical Devices (& Hospital Services) • Real Estate (& Construction) • Healthcare (& Wellness) • Woman Focused

Description

Most Interested In

Labor marketplaces and vertical markets. Vertical markets might include real estate, education, construction, healthcare, or any other large market that has been resistant to change.

Not Interested In

I've made a lot of SaaS investments in the past, but I'm interested in software companies that have a distribution hook.

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Parikshit Sharma
Investing in BioTech • AgroTech • Energ...
 San Francisco Bay Area, U.S.A.
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Parikshit Sharma

San Francisco Bay Area, U.S.A.

Investing In

BioTech • AgroTech • Energy • HealthTech (& Fitness) • Food & Beverage • Impact • Material Science • Medical Devices (& Hospital Services) • Healthcare (& Wellness) • Consumer • Pharmaceutical (& Medicine) • Woman Focused

Description

Principal at SOSV

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Randall Crowder
Investing in Software (Web Marketplace Saas..) &b...
 Austin, U.S.A.
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Previous Investments
  • BetterDoctor: $11000000 (Later stage VC)
  • Ortho Kinematics: $9600000 (Later stage VC)
  • CareDox: $2800000 (Seed Round)
  • IsoStem: $1300000 (Early stage VC)
  • Sensentia: $1250000 (Other)
  • Televero: (Later stage VC)
  • EmployerDirect Healthcare: (Later stage VC)
  • Novē Ventures:
  • PhunCoin:
  • Phunware, Inc.: (late stage)
  • The Watchers Eye | The Crypto Watch:
  • Employer Direct Healthcare: (early stage)
  • Limestone Ventures: (early stage)
  • Texas Venture Labs: (early stage)
  • TEXO Ventures: (early stage)
  • Wenzel Spine:
  • Central Texas Angel Network: (early stage)
  • SwipeSense: $9700000 (Series B)
  • SwipeSense: $10000000 (Series B)
  • SwipeSense: $1700000 (Series A)
  • SwipeSense: $2000000 (Series A)
  • SwipeSense: $930000 (Series Unknown)
  • SwipeSense: (Series A)
  • OpenMarkets: (Series A)
  • OpenMarkets: (Series A)
  • OpenMarkets: (Series A)

Randall Crowder

Austin, U.S.A.

Investing In

Software (Web Marketplace Saas..) • HealthTech (& Fitness) • Medical Devices (& Hospital Services)

Description

Chief Operations Officer (and Chief Blockchain Champion) at Phunware, Inc.

Chief Operations Officer (and Chief Blockchain Champion) at Phunware, Inc.

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Janelle Goulard
Investing in BioTech • AgroTech • Clean...
 Phoenix - Arizona, U.S.A. - Canada
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Previous Investments
  • Modulated Imaging: $7000000 (Series B)
  • Calysta Energy: $30000000 (Later stage VC)
  • ESS, Inc.: $13000000 (Later stage VC)
  • Airborne: $12000000 (Other)
  • Correlia Biosystems: $9570000 (Early stage VC)
  • CarbonCure Technologies: $1750000 (Later stage VC)
  • Tivra: $50000 (Early stage VC)
  • Aspect Biosystems: (Later stage VC)
  • Biodel AG: (Series A)
  • Modulim: $7000000 (Series B)

Janelle Goulard

Phoenix - Arizona, U.S.A. - Canada

Investing In

BioTech • AgroTech • CleanTech • Impact • Material Science • Medical Devices (& Hospital Services) • Woman Focused

Description

Hardtech Impact Investor

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Michael Gorman
Investing in Software (Web Marketplace Saas..) &b...
 Minnesota, United States
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Previous Investments
  • Gravie: (early stage)
  • Sparkcentral: (early stage)
  • VoloMetrix: (mid stage)
  • BlueKai: (mid stage)
  • Black Duck Software: (late stage)
  • TruSignal: (early stage)
  • Calabrio, Inc.: (early stage)
  • eBureau:
  • Split Rock Partners:
  • HighJump Software:
  • Adaytum Software:
  • Lawson Software:
  • SPS Commerce:

Michael Gorman

Minnesota, United States

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • Businesses Solutions • HealthTech (& Fitness) • Web Security (& Privacy) • Insurance (& InsurTech) • Medical Devices (& Hospital Services)

Description

Software and Internet Services Investor

Software and Internet Services Investor

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Jon Broscious
Investing in Software (Web Marketplace Saas..) &b...
 Seattle , Boston , Ch..., U.S.A.
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Previous Investments
  • Treads: $5000000 (Seed)

Jon Broscious

Seattle - Boston - Chicago - Atlanta - Washington - Detroit - San Francisco Bay Area - Austin - New York - Los Angeles - Texas, U.S.A.

Investing In

Software (Web Marketplace Saas..) • Education • FinTech (& Financials services) • HealthTech (& Fitness) • Insurance (& InsurTech) • Medical Devices (& Hospital Services) • Healthcare (& Wellness)

Description

Most Interested In

- consumer (DNVBs + marketplaces) - market based education - market based healthcare - vertical SaaS (healthc, edu, agtech, construction, others) - blockchain - AR/VR/MR/voice interfaces and middleware -food and beverage

Not Interested In

pharma

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Martyn Eeles
Investing in BioTech • HealthTech (& Fitness...
 San Francisco Bay Are..., U.S.A.
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Previous Investments
  • Wealth Advisor Ratings: $25000 (PreSeed)

Martyn Eeles

San Francisco Bay Area - California, U.S.A.

Investing In

BioTech • HealthTech (& Fitness) • Medical Devices (& Hospital Services) • Healthcare (& Wellness) • Consumer • Pharmaceutical (& Medicine) • Woman Focused

Description

Most Interested In

Financial marketplaces.

Not Interested In

Food and Beverage

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Brad Bao
Investing in Software (Web Marketplace Saas..) &b...
 Redwood City, U.S.A. - China
Investor Picture
Previous Investments
  • Aware Healthcare: $4000000 (Seed)
  • KiwiDrop: (Pre Seed)
  • Shackle: $15000000 (Series A)
  • Shackle: $6000000 (Seed)
  • Titan: $4000000 (Seed)
  • Jupiter: $5000000 (Seed)
  • Channel AI: $20000000 (Series A)
  • Swimply: $40000000 (Series Unknown)
  • Doublefin: (Seed)
  • Firefly: $22000000 (Seed)
  • Firefly: $22000000 (Seed Round)
  • Got It AI: (Seed)
  • inui Health: $35000000 (Series B)
  • Remark: $2000000 (Seed)

Brad Bao

Redwood City, U.S.A. - China

Investing In

Software (Web Marketplace Saas..) • Media • Education • Businesses Solutions • FinTech (& Financials services) • Retail (& E-Commerce) • Gaming (& eSports) • Medical Devices (& Hospital Services) • Healthcare (& Wellness) • Online Social

Description

Unlock Life


Managing Partner at Kinzon Capital (Fosun Group), ex-General Manager of Tencent US branch (8 years); Internet expert of both US and China market

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Uri Zilberman
Investing in Software (Web Marketplace Saas..) &b...
 New York - New Jersey, U.S.A. - Israel
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Uri Zilberman

New York - New Jersey, U.S.A. - Israel

Investing In

Software (Web Marketplace Saas..) • FinTech (& Financials services) • Energy • IoT (& Wearables) • A.I. (& Big Data) • HealthTech (& Fitness) • Web Security (& Privacy) • Cloud Services (& Infrastructure) • Medical Devices (& Hospital Services) • Mobility

Description

Most Interested In

AI/ML Security Autonomous cars SaaS MedTech FinTech Any early-stage technology/idea that can have an impact....

Not Interested In

Are you an early stage team with a disruptive idea? We help founders bring ideas to life. We can lead Pre-Seed, Seed, and help through a successful A round. We tend to get more involved in B2B or B2B2C business models and look for companies in early to early-early stages.... An areas we can add the most value.

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Christine Tsai
Investing in PropTech • Hardware (& Manufact...
 Palo Alto , San Franc..., U.S.A. - U.K. - South Korea - Japan
Investor Picture
Previous Investments
  • GoPillar (CoContest): $620000 (Seed Round)
  • Kin Insurance: $82000000 (Later stage VC)
  • Grin (e: (scooters))
  • Carsome: $20000000 (Later stage VC)
  • SmartHR: $13300000 (Later stage VC)
  • LottieFiles: $9000000 (Early stage VC)
  • Indio Technologies: $6000000 (Early stage VC)
  • CreditStacks: $4000000 (Seed Round)
  • Ghinwa: $3000000 (Seed Round)
  • Naluri Hidup: $1000000 (Seed Round)
  • Krosslinker: $920000 (Seed Round)
  • Osome: $150000 (Seed Round)
  • Nestrom: (Seed Round)
  • Grain: (Later stage VC)
  • Finedine Menu: (Seed Round)
  • BlockCypher Hijro burstIQ Libra Credit Network MedStack:
  • Sabbar:
  • Snapshyft:
  • Intrepid Group Asia:
  • TartanHQ: $5000000 (Seed)
  • Stack: $850000 (Seed)
  • Abound: $650000 (Pre Seed)
  • ProSky: $2400000 (Seed Round)
  • ProSky: $2000000 (Seed)
  • ProSky: $380000 (Seed)
  • Alphaus: $130000 (Seed)
  • Barn & Willow: $130000 (Seed Round)
  • Barn & Willow: $130000 (Seed)
  • GoPillar: $620000 (Seed)
  • Headout: $2000000 (Seed)
  • AstroPrint: $300000 (Seed)
  • AppZen: (Seed)
  • ViralGains: $3000000 (Seed)
  • Partender: (Seed)
  • Partender: $50000 (Seed)
  • CultureMap: $750000 (Seed)
  • Geekatoo: $500000 (Seed)
  • Friend Trusted: (Seed)
  • MailLift: $50000 (Seed)
  • Binpress: $1000000 (Seed)
  • Reesio: $210000 (Seed)
  • Reesio: $210000 (Seed Round)
  • Floqq: $50000 (Seed)
  • CapLinked: $900000 (Seed)

Christine Tsai

Palo Alto - San Francisco Bay Area, U.S.A. - U.K. - South Korea - Japan

Investing In

PropTech • Hardware (& Manufacturing) • Retail (& E-Commerce) • Sales (& Marketing) • Cosmetics (& Fashion) • IoT (& Wearables) • HealthTech (& Fitness) • Medical Devices (& Hospital Services) • Real Estate (& Construction) • Healthcare (& Wellness) • Consumer

Description

CEO and Founding Partner at 500 Startups

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Aaron Jacobson
Investing in BioTech • HealthTech (& Fitness...
 San Francisco Bay Are..., U.S.A. - Israel
Investor Picture
Previous Investments
  • Amplyx: $118280000 (Later stage VC)
  • Allakos: $100000000 (Later stage VC)
  • Korro Bio: $91500000 (Later stage VC)
  • Bestow: $70000000 (Later stage VC)
  • Pionyr Immunotherapeutics: $62000000 (Later stage VC)
  • Sitetracker: $42000000 (Later stage VC)
  • DataVisor: $40000000 (Later stage VC)
  • FIRE1: $40000000 (Later stage VC)
  • Xoc Pharmaceuticals: $30000000 (Early stage VC)
  • MindTickle: $27000000 (Later stage VC)
  • Logikcull: $25000000 (Later stage VC)
  • Infoworks: $25000000 (Later stage VC)
  • Metacrine: $22000000 (Later stage VC)
  • Fyusion: $22000000 (Later stage VC)
  • Drop: $21000000 (Early stage VC)
  • Greenlight Financial Technology: $16000000 (Early stage VC)
  • Lyric: $15500000 (Early stage VC)
  • Igneous Systems: $15000000 (Later stage VC)
  • Timescale: $12400000 (Early stage VC)
  • Akouos: $7500000 (Seed Round)
  • Curisium: $3500000 (Seed Round)
  • Aquabyte: $3500000 (Seed Round)
  • Genies: $3000000 (Other)
  • Lily: $2000000 (Seed Round)
  • Vizbee: (Later stage VC)
  • Second Front Systems: (Series Unknown)
  • Second Front Systems: $40000000 (Series B)
  • Martian: $9000000 (Seed)
  • Pulumi: $41000000 (Series C)
  • Pulumi: $38000000 (Series B)
  • Embrace: $20000000 (Series Unknown)
  • Embrace: $45000000 (Series B)
  • Flox: $17000000 (Series A)
  • Crowdbotics: $40000000 (Series B)
  • ForAllSecure: $21000000 (Series B)
  • Rapid Robotics: $37000000 (Series B)
  • Rapid Robotics: $12000000 (Series A)
  • Bitglass: $70000000 (Series D)
  • Bitglass: $45000000 (Series C)
  • Bitglass: $25000000 (Series B)
  • Bitglass: $10000000 (Series A)
  • Tigera: $30000000 (Series B)
  • Tigera: $10000000 (Series A)
  • Tigera: $13000000 (Series A)
  • Console Connect: $26000000 (Series B)
  • Console Connect: $10000000 (Series A)
  • Illusive Networks: $22000000 (Series B)
  • Mimosa: $20000000 (Series C)
  • Dreamfactory Software: $2000000 (Series B)

Aaron Jacobson

San Francisco Bay Area - New York, U.S.A. - Israel

Investing In

BioTech • HealthTech (& Fitness) • Medical Devices (& Hospital Services) • Healthcare (& Wellness) • Consumer • Pharmaceutical (& Medicine)

Description

Most Interested In AI / ML, Microservices and Devops, Cybersecurity, Industrial AI / Automation and Robotics Not Interested In eCommerce, Adtech, Healthcare

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