The United states Startup Ecosystem

Overview

The United States boasts the largest and most dynamic startup ecosystem in the world, with major hubs like Silicon Valley, New York City, and Boston. This ecosystem is characterized by a strong venture capital presence and a supportive culture for innovation and entrepreneurship. The U.S. continues to lead globally in technological innovation and startup activity, contributing significantly to economic growth and job creation.

Size of the Market

As of 2024, the U.S. is home to approximately 77,927 startups. The startup ecosystem is supported by substantial venture capital investments, which totaled around $162.6 billion in 2022. This robust financial backing highlights the confidence investors have in the U.S. startup market, ensuring ample funding for innovation and growth.

Key Strengths

Key strengths of the U.S. market include a highly skilled workforce, advanced technological infrastructure, and a culture that encourages risk-taking and entrepreneurship. The presence of major tech companies like Google, Apple, and Facebook fosters a collaborative environment and provides ample opportunities for startups. Additionally, the U.S. government offers support through various grants and tax incentives, such as the Small Business Innovation Research (SBIR) program.

Major Hubs

Silicon Valley remains the epicenter of innovation, driving advancements in AI, biotechnology, fintech, and clean energy. New York City excels in finance and media, while Boston is strong in biotechnology and education-driven startups. These regions are crucial to the U.S. startup ecosystem, offering a wealth of resources, talent, and opportunities.

Emerging Hubs

Cities like Austin, Denver, and Seattle are emerging as significant tech hubs. These cities provide a favorable business climate, quality of life, and are becoming attractive locations for startups and talent. The rise of remote work has further expanded opportunities for startups to access talent from various regions, contributing to the growth of these emerging hubs.

Support Systems

The U.S. startup market benefits from a comprehensive support system of accelerators, incubators, and co-working spaces. Programs like Techstars and Y Combinator have been instrumental in nurturing early-stage startups, providing mentorship, resources, and funding. These support systems help startups at various stages of their journey to scale and succeed.

Challenges

Despite its strengths, the U.S. startup ecosystem faces challenges such as high costs of living, regulatory hurdles, and intense competition for talent. These challenges can create barriers for new startups and require strategic navigation to ensure long-term success.

Opportunities and Future Outlook

The U.S. startup market features a diverse customer base and a culture that encourages innovation and entrepreneurship. The rise of remote work has expanded opportunities, allowing startups to access talent from various regions. The future outlook remains positive with continuous growth and innovation, driven by emerging technologies such as blockchain, quantum computing, and green energy.

Resilience and Adaptability

The U.S. startup ecosystem is characterized by its resilience and adaptability. Despite challenges, the ecosystem continues to evolve, driven by a strong culture of entrepreneurship and technological advancements. This ensures the U.S. remains at the forefront of global innovation, contributing significantly to economic growth and job creation.

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We found 3,911 VC firms in the United states investing in Material Science on Angels Partners

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Ian Rountree
Investing in BioTech • Hardware (& Manufactu...
 San Francisco Bay Are..., U.S.A.
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Previous Investments
  • Ava (Application):
  • Mako Aerospace: $700000 (Pre Seed Round)
  • Venus Aerospace: $20000000 (Series A)
  • Venus Aerospace: (Seed Round)
  • Venus Aerospace: $3200000 (Seed Round)
  • Radiant: $13000000 (Series A)
  • Atomos Space: $5000000 (Venture Round)
  • Sixfold Bioscience: $2200000 (Seed Round)
  • Debut: $23000000 (Series A)
  • Debut: $2600000 (Seed Round)
  • Phenomic AI: $6000000 (Seed Round)
  • Phenomic AI: $2000000 (Seed Round)
  • Circularis Biotechnologies: (Seed Round)
  • Character Biosciences: $6000000 (Seed Round)
  • Eridan: $8000000 (Series A)
  • Lively: $4200000 (Seed Round)
  • Rental Beast: $5000000 (Venture Round)
  • EasyPost: $4000000 (Seed Round)
  • EasyPost: $1200000 (Seed Round)
  • Public.com: $15000000 (Series B)
  • Clover Therapeutics: $3600000 (Seed)
  • Astranis: $40000000 (Series B)
  • Debut Biotechnology: (Seed)
  • Eridan Communications, Inc.: $7500000 (Series A)
  • Pow.bio: $1500000 (Pre-Seed)
  • XGenomes: $3000000 (Seed)
  • Concha Labs: $500000 (Pre-Seed)
  • Humane: $9000000 (Seed)
  • Chameleon Biosciences: $3000000 (Seed)
  • Phenomic: (Seed)
  • Mission Barns: $3500000 (Seed)
  • Atom Computing: (Seed)
  • Skyryse: $15000000 (Series A)
  • Vence: $1600000 (Pre-Seed)
  • Clara Health: $3000000 (Seed)
  • Opus 12: $2800000 (Pre-Seed)
  • Knowde: $1500000 (Pre-Seed)
  • Helium Health: $2500000 (Seed)
  • Visolis: $3400000 (Seed)
  • Qwil: $1600000 (Seed)
  • ADVANO: $4500000 (Seed)
  • Catalog Technologies: $5000000 (Seed)
  • Arable: $3000000 (Seed)
  • Anagram, Inc.: $3500000 (Seed)
  • Ethic: $1400000 (Pre-Seed)
  • ALICE Technologies: (seed)
  • Superhuman: (Series B)

Ian Rountree

San Francisco Bay Area - California, U.S.A.

Investing In

BioTech • Hardware (& Manufacturing) • Energy • CleanTech • Impact • Material Science • Robotics • Aerospace (& Defense) • Woman Focused

Description

Views best described as cosmopolitan-cum-extropian

Most Interested In

Where the intersection of software, hardware, & wetware can create value in over a billion lives this decade––esp. industrial bio, aerospace, industrial robotics, next-gen computing hardware, and drug development.

Not Interested In

CPG, mobile-first, ad/marketing/sales, hiring-tech, anything that could have been built more than 2-3 years ago. Nor cannabis, therapeutics, or medical devices.


Most Interested In

Where the intersection of software, hardware, & wetware can create value in over a billion lives this decade––esp. industrial bio, industrial robotics, next-gen computing hardware, and drug development.

Not Interested In

CPG, mobile-first, ad/marketing/sales, hiring-tech, anything that could have been built more than 2-3 years ago. Nor cannabis, therapeutics, or medical devices.


Ian Rountree is the Founder of Cantos Ventures. He is an Agent and Chief of Staff at Invisible Technologies.

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Parikshit Sharma
Investing in BioTech • AgroTech • Energ...
 San Francisco Bay Area, U.S.A.
Investor Picture

Parikshit Sharma

San Francisco Bay Area, U.S.A.

Investing In

BioTech • AgroTech • Energy • HealthTech (& Fitness) • Food & Beverage • Impact • Material Science • Medical Devices (& Hospital Services) • Healthcare (& Wellness) • Consumer • Pharmaceutical (& Medicine) • Woman Focused

Description

Principal at SOSV

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Janelle Goulard
Investing in BioTech • AgroTech • Clean...
 Phoenix - Arizona, U.S.A. - Canada
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Previous Investments
  • Modulated Imaging: $7000000 (Series B)
  • Calysta Energy: $30000000 (Later stage VC)
  • ESS, Inc.: $13000000 (Later stage VC)
  • Airborne: $12000000 (Other)
  • Correlia Biosystems: $9570000 (Early stage VC)
  • CarbonCure Technologies: $1750000 (Later stage VC)
  • Tivra: $50000 (Early stage VC)
  • Aspect Biosystems: (Later stage VC)
  • Biodel AG: (Series A)
  • Modulim: $7000000 (Series B)

Janelle Goulard

Phoenix - Arizona, U.S.A. - Canada

Investing In

BioTech • AgroTech • CleanTech • Impact • Material Science • Medical Devices (& Hospital Services) • Woman Focused

Description

Hardtech Impact Investor

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Brian Melton
Investing in Software (Web Marketplace Saas..) &b...
 California, United States
Investor Picture
Previous Investments
  • LeanData, Inc.: (late stage)
  • Valimail: (mid stage)
  • Wavefront Inc.: (mid stage)
  • Optimizely: (late stage)
  • Revinate: (late stage)
  • Bluebox Security: (early stage)
  • Capriza: (mid stage)
  • Hortonworks: (early stage)
  • Instart Logic:
  • CloudPassage: (mid stage)
  • New Relic, Inc.: (early stage)
  • RightScale: (mid stage)
  • Lithium Technologies: (late stage)
  • Zuora: (early stage)
  • VeriSilicon Holdings Co., Ltd.: (late stage)
  • Active-Semi International: (early stage)
  • Tenaya Capital: (early stage)

Brian Melton

California, United States

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • Hardware (& Manufacturing) • Energy • CleanTech • A.I. (& Big Data) • Web Security (& Privacy) • Material Science

Description

Managing Director at Tenaya Capital

Managing Director at Tenaya Capital

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Stewart Gollmer
Investing in Software (Web Marketplace Saas..) &b...
 Portola Valley, Calif..., United States
Investor Picture
Previous Investments
  • Druva: $80000000 (Later stage VC)
  • Apartment List: $60000000 (Later stage VC)
  • ResearchGate: $52600000 (Later stage VC)
  • Numerify: $27500000 (Later stage VC)
  • Lola Travel Company, Inc.: $25000000 (Later stage VC)
  • Inkling Systems: $25000000 (Later stage VC)
  • Armis Security: $17000000 (Later stage VC)
  • Plays.tv: $15000000 (Early stage VC)
  • Avere Systems: $14000000 (Later stage VC)
  • Canopy (Tax Software): $13000000 (Later stage VC)
  • Headstart: $1000000 (Seed Round)
  • Lyra Health: (mid stage)
  • Base CRM: (late stage)
  • Health Catalyst: (late stage)
  • Brighter: (early stage)
  • CareCloud: (mid stage)
  • Tealium: (mid stage)
  • SilkRoad technology: (late stage)
  • ThreatMetrix: (mid stage)
  • Cyan Optics:
  • Lucky Pai:
  • Tenaya Capital: (early stage)
  • Storwize:
  • AOptix Technologies: (late stage)
  • Cast Iron Systems:
  • Overture Networks: (late stage)
  • TeleNav: (late stage)
  • Health Language, Inc.:
  • Kodiak Networks: (early stage)
  • Navini Networks:
  • comScore, Inc.: (mid stage)
  • Lehman Brothers:

Stewart Gollmer

Portola Valley, California, United States

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • Hardware (& Manufacturing) • Energy • CleanTech • Web Security (& Privacy) • Material Science • Investment Management • Mobile

Description

Managing Director at Tenaya Capital

Managing Director at Tenaya Capital

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George Kadifa
Investing in Software (Web Marketplace Saas..) &b...
 California, United States
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Previous Investments
  • Ceros: (late stage)
  • GoGuardian: (mid stage)
  • Sumeru Equity Partners:
  • Silver Lake Partners: (late stage)

George Kadifa

California, United States

Investing In

Software (Web Marketplace Saas..) • Other • Education • Businesses Solutions • Energy • CleanTech • Material Science • Productivity

Description

Managing Director, Sumeru Equity Partners

Managing Director, Sumeru Equity Partners

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Eric Desai
Investing in Energy • CleanTech • Insur...
 Sausalito, California, United States
Investor Picture
Previous Investments
  • Afresh: $25000000 (Later stage VC)
  • InsideView: $12000000 (Later stage VC)
  • Bespoke Financial: $7000000 (Early stage VC)
  • Revive Kombucha: $2100000 (Early stage VC)
  • Lifefactory: $1650000 (Early stage VC)
  • Linkage Biosciences: $1545000 (Later stage VC)
  • Rensource Energy: $1100000 (Seed Round)
  • SureGifts: $300000 (Seed Round)
  • Mines.io: (Seed Round)
  • Akbank:
  • JPMorgan Chase:
  • European Bank for Reconstruction and Development (EBRD): (mid stage)
  • White & Case:
  • 120WaterAudit: (mid stage)
  • Greenhouse Capital Partners: (late stage)
  • Robin Lane Capital:
  • Revolution Foods: (late stage)
  • PricewaterhouseCoopers Advisory NV (Netherlands):

Eric Desai

Sausalito, California, United States

Investing In

Energy • CleanTech • Insurance (& InsurTech) • Material Science • Healthcare (& Wellness) • Investment Management

Description

Partner at Greenhouse Capital Partners

Partner at Greenhouse Capital Partners

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Joe Horowitz
Investing in IT (& TMT) • Media • Hardw...
 California, United States
Investor Picture
Previous Investments
  • Global Worldwide:
  • National Venture Capital Association:
  • Thanx: (mid stage)
  • TheMuse: (mid stage)
  • Area 1 Security: (early stage)
  • Synack: (early stage)
  • PLAYSTUDIOS: (mid stage)
  • TuneIn:
  • KIXEYE: (early stage)
  • Posterous (Twitter): (mid stage)
  • Sencha (IDERA):
  • Clicker Media Inc (CBS): (early stage)
  • Meebo (Google): (mid stage)
  • Ocarina Networks (Dell): (early stage)
  • Palo Alto Networks (PANW): (mid stage)
  • true[x] media (Fox): (early stage)
  • Oodle (QVC): (mid stage)
  • RedSeal Networks: (mid stage)
  • SiTime (MegaChips): (early stage)
  • FireEye, Inc. (FEYE): (early stage)
  • Avnera Corporation (Skyworks):
  • Cortina Systems (Inphi): (mid stage)
  • Mimosa Systems (Iron Mountain):
  • Proofpoint (PFPT): (mid stage)
  • Devicescape: (early stage)
  • Icon Ventures: (early stage)
  • Infinera (INFN): (early stage)
  • ICON Venture Advisors:
  • US Venture Partners:

Joe Horowitz

California, United States

Investing In

IT (& TMT) • Media • Hardware (& Manufacturing) • Energy • CleanTech • Web Security (& Privacy) • Material Science

Description

Managing General Partner at Icon Ventures

Managing General Partner at Icon Ventures

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Patrick Sagisi
Investing in Energy • A.I. (& Big Data) &bul...
 Menlo Park, California, United States
Investor Picture
Previous Investments
  • Heila Technologies: $70000 (Seed Round)
  • Electriphi Inc:
  • Acario Ventures / Acario Innovation:
  • DBL Partners:
  • Mapbox: (mid stage)
  • Trove: (early stage)
  • UrbanSitter: (mid stage)
  • DBL Investors:
  • Kateeva: (mid stage)
  • OPX Biotechnologies, Inc.: (mid stage)
  • Siva Power: (early stage)
  • ZincFive, Inc.: (early stage)
  • San Francisco 2012/BASOC:

Patrick Sagisi

Menlo Park, California, United States

Investing In

Energy • A.I. (& Big Data) • Material Science • Robotics • Real Estate (& Construction) • Mobility

Description

New Energy & Sustainability VC

New Energy & Sustainability VC

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Doug Sills
Investing in Media • BioTech • Business...
 Los Angeles - California, U.S.A.
Investor Picture
Previous Investments
  • Rollick: $8270000 (Early stage VC)
  • Darvis:

Doug Sills

Los Angeles - California, U.S.A.

Investing In

Media • BioTech • Businesses Solutions • FinTech (& Financials services) • Blockchain (& Cryptos) • Web Security (& Privacy) • Cloud Services (& Infrastructure) • Material Science • Payments • Pharmaceutical (& Medicine)

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Manan Mehta
Investing in Software (Web Marketplace Saas..) &b...
 Denver , Washington ,..., U.S.A. - Canada
Investor Picture
Previous Investments
  • Ubiquitilink: (Seed Round)
  • Plutoshift: $6770000 (Early stage VC)
  • Pluto AI: $2100000 (Seed Round)
  • Lily: $2000000 (Seed Round)
  • Sote: $150000 (Other)
  • Brite Health: (Seed Round)
  • OnTarget: (Seed Round)
  • Starsky Robotics: (Seed Round)
  • Masa: $5000000 (Seed)
  • Masa: $4000000 (Pre Seed)
  • Career Karma: $10000000 (Series A)
  • Career Karma: $2000000 (Seed)

Manan Mehta

Denver - Washington - Los Angeles / Southern California - San Francisco Bay Area - New York, U.S.A. - Canada

Investing In

Software (Web Marketplace Saas..) • AgroTech • Businesses Solutions • Retail (& E-Commerce) • CleanTech • A.I. (& Big Data) • Material Science • Robotics • DeepTech • Nanotechnology • Woman Focused

Description

Founding Partner at Unshackled Ventures


Most Interested In

Immigrant entreprenuers. We provide 3 things: Your scalable friends and family capital, full immigration support, including sponsorship and stewardship to help you succeed faster. Our goal is to make investment decisions in 3 meetings over 2 hours.

Not Interested In

Non-immigrant founders.


Founder @unshackled - Investor. Entrepreneur. Love being at the intersection of do good, do well.

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Cynthia Ringo
Investing in IT (& TMT) • BioTech • Har...
 San Francisco California, U.S.A.
Investor Picture
Previous Investments
  • Mapbox: $164000000 (Later stage VC)
  • Wheels (Automotive): $50000000 (Later stage VC)
  • Primus Power: $32000000 (Later stage VC)
  • BrainScope Company: $16000000 (Later stage VC)
  • Zero Systems:
  • Better Place Forests: $7500000 (Early stage VC)

Cynthia Ringo

San Francisco California, U.S.A.

Investing In

IT (& TMT) • BioTech • Hardware (& Manufacturing) • CleanTech • Material Science • Healthcare (& Wellness) • Investment Management • Mobile • Mobility • Restaurants

Description

DBL Partners was formed in 2015 from the combination of DBL Investors and the Cleantech practice of Technology Partners. The firm uses venture capital to accelerate innovation in a way that affects an organization's social impact, as well as its financial success. It is headquartered in San Francisco, California and seeks to invest in the clean tech, information technology, sustainable products and services, and healthcare sectors.

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