The United states Startup Ecosystem

Overview

The United States boasts the largest and most dynamic startup ecosystem in the world, with major hubs like Silicon Valley, New York City, and Boston. This ecosystem is characterized by a strong venture capital presence and a supportive culture for innovation and entrepreneurship. The U.S. continues to lead globally in technological innovation and startup activity, contributing significantly to economic growth and job creation.

Size of the Market

As of 2024, the U.S. is home to approximately 77,927 startups. The startup ecosystem is supported by substantial venture capital investments, which totaled around $162.6 billion in 2022. This robust financial backing highlights the confidence investors have in the U.S. startup market, ensuring ample funding for innovation and growth.

Key Strengths

Key strengths of the U.S. market include a highly skilled workforce, advanced technological infrastructure, and a culture that encourages risk-taking and entrepreneurship. The presence of major tech companies like Google, Apple, and Facebook fosters a collaborative environment and provides ample opportunities for startups. Additionally, the U.S. government offers support through various grants and tax incentives, such as the Small Business Innovation Research (SBIR) program.

Major Hubs

Silicon Valley remains the epicenter of innovation, driving advancements in AI, biotechnology, fintech, and clean energy. New York City excels in finance and media, while Boston is strong in biotechnology and education-driven startups. These regions are crucial to the U.S. startup ecosystem, offering a wealth of resources, talent, and opportunities.

Emerging Hubs

Cities like Austin, Denver, and Seattle are emerging as significant tech hubs. These cities provide a favorable business climate, quality of life, and are becoming attractive locations for startups and talent. The rise of remote work has further expanded opportunities for startups to access talent from various regions, contributing to the growth of these emerging hubs.

Support Systems

The U.S. startup market benefits from a comprehensive support system of accelerators, incubators, and co-working spaces. Programs like Techstars and Y Combinator have been instrumental in nurturing early-stage startups, providing mentorship, resources, and funding. These support systems help startups at various stages of their journey to scale and succeed.

Challenges

Despite its strengths, the U.S. startup ecosystem faces challenges such as high costs of living, regulatory hurdles, and intense competition for talent. These challenges can create barriers for new startups and require strategic navigation to ensure long-term success.

Opportunities and Future Outlook

The U.S. startup market features a diverse customer base and a culture that encourages innovation and entrepreneurship. The rise of remote work has expanded opportunities, allowing startups to access talent from various regions. The future outlook remains positive with continuous growth and innovation, driven by emerging technologies such as blockchain, quantum computing, and green energy.

Resilience and Adaptability

The U.S. startup ecosystem is characterized by its resilience and adaptability. Despite challenges, the ecosystem continues to evolve, driven by a strong culture of entrepreneurship and technological advancements. This ensures the U.S. remains at the forefront of global innovation, contributing significantly to economic growth and job creation.

Angel Investment trends in the United states

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We found 3,814 VC firms in the United states investing in Material Science on Angels Partners

Janelle Goulard
Investing in BioTech • AgroTech • Clean...
 Phoenix - Arizona, U.S.A. - Canada
Investor Picture
Previous Investments
  • Modulated Imaging: $7000000 (Series B)
  • Calysta Energy: $30000000 (Later stage VC)
  • ESS, Inc.: $13000000 (Later stage VC)
  • Airborne: $12000000 (Other)
  • Correlia Biosystems: $9570000 (Early stage VC)
  • CarbonCure Technologies: $1750000 (Later stage VC)
  • Tivra: $50000 (Early stage VC)
  • Aspect Biosystems: (Later stage VC)
  • Biodel AG: (Series A)
  • Modulim: $7000000 (Series B)

Janelle Goulard

Phoenix - Arizona, U.S.A. - Canada

Investing In

BioTech • AgroTech • CleanTech • Impact • Material Science • Medical Devices (& Hospital Services) • Woman Focused

Description

Hardtech Impact Investor

Caleb Clark
Investing in Software (Web Marketplace Saas..) &b...
 Waltham Massachusetts..., United States
Investor Picture
Previous Investments
  • Mckenzie Sports Products:
  • Genstar Capital:

Caleb Clark

Waltham Massachusetts - Newport California, United States

Investing In

Software (Web Marketplace Saas..) • Businesses Solutions • FinTech (& Financials services) • Hardware (& Manufacturing) • Entertainment (& Sports) • HealthTech (& Fitness) • Food & Beverage • Logistics (& Distribution) • Material Science

Description

Board Member at Accupac

With offices in both Newport Beach and Boston, Windjammer is a national private investment firm which invests control equity, minority equity and subordinated debt in leading middle market businesses. Founded in 1990, Windjammer has successfully raised four institutional funds totaling over $1.8 billion of capital and is currently investing out of its latest fund with over $575 million in commitments. Windjammer seeks to invest between $30 million and $140 million of equity or subordinated debt in middle market companies with a minimum EBITDA of $10 million and up to $40 million. Windjammer seeks investment opportunities across the U.S. and Canada, primarily in three industry segments: niche manufacturing, business services, and value-added distribution. Additionally, prior investments have included: Industrial Automation Control Equipment, Engineered Medical Tools, Private Label Consumer Products, Water Industry Equipment, Community Newspapers, and Healthcare Products and Services. Windjammer does not invest in high tech, real estate, and financial services companies. In addition, investments in operational turnarounds and early stage companies are avoided.

Joe Horowitz
Investing in IT (& TMT) • Media • Hardw...
 California, United States
Investor Picture
Previous Investments
  • Global Worldwide:
  • National Venture Capital Association:
  • Thanx: (mid stage)
  • TheMuse: (mid stage)
  • Area 1 Security: (early stage)
  • Synack: (early stage)
  • PLAYSTUDIOS: (mid stage)
  • TuneIn:
  • KIXEYE: (early stage)
  • Posterous (Twitter): (mid stage)
  • Sencha (IDERA):
  • Clicker Media Inc (CBS): (early stage)
  • Meebo (Google): (mid stage)
  • Ocarina Networks (Dell): (early stage)
  • Palo Alto Networks (PANW): (mid stage)
  • true[x] media (Fox): (early stage)
  • Oodle (QVC): (mid stage)
  • RedSeal Networks: (mid stage)
  • SiTime (MegaChips): (early stage)
  • FireEye, Inc. (FEYE): (early stage)
  • Avnera Corporation (Skyworks):
  • Cortina Systems (Inphi): (mid stage)
  • Mimosa Systems (Iron Mountain):
  • Proofpoint (PFPT): (mid stage)
  • Devicescape: (early stage)
  • Icon Ventures: (early stage)
  • Infinera (INFN): (early stage)
  • ICON Venture Advisors:
  • US Venture Partners:

Joe Horowitz

California, United States

Investing In

IT (& TMT) • Media • Hardware (& Manufacturing) • Energy • CleanTech • Web Security (& Privacy) • Material Science

Description

Managing General Partner at Icon Ventures

Managing General Partner at Icon Ventures

Patrick Sagisi
Investing in Energy • A.I. (& Big Data) &bul...
 Menlo Park, California, United States
Investor Picture
Previous Investments
  • Heila Technologies: $70000 (Seed Round)
  • Electriphi Inc:
  • Acario Ventures / Acario Innovation:
  • DBL Partners:
  • Mapbox: (mid stage)
  • Trove: (early stage)
  • UrbanSitter: (mid stage)
  • DBL Investors:
  • Kateeva: (mid stage)
  • OPX Biotechnologies, Inc.: (mid stage)
  • Siva Power: (early stage)
  • ZincFive, Inc.: (early stage)
  • San Francisco 2012/BASOC:

Patrick Sagisi

Menlo Park, California, United States

Investing In

Energy • A.I. (& Big Data) • Material Science • Robotics • Real Estate (& Construction) • Mobility

Description

New Energy & Sustainability VC

New Energy & Sustainability VC

Steve Moore
Investing in IT (& TMT) • Education • B...
 New York, United States
Investor Picture
Previous Investments
  • Akido Labs: (mid stage)
  • Spot:
  • CleverPet: (mid stage)
  • SPORTLOGiQ: (early stage)
  • STRIVR Labs, Inc.: (early stage)
  • Health Smart Financial Services: (late stage)
  • PayBright: (late stage)
  • The Steve Moore Foundation: (early stage)

Steve Moore

New York, United States

Investing In

IT (& TMT) • Education • Businesses Solutions • Hardware (& Manufacturing) • Entertainment (& Sports) • CleanTech • HealthTech (& Fitness) • Logistics (& Distribution) • Material Science • Aerospace (& Defense)

Description

Investor at Spot

Investor at Spot

Nikhil Patel
Investing in IT (& TMT) • Education • B...
 New York, United States
Investor Picture
Previous Investments
  • Dell Technologies: (mid stage)
  • OmniView Sports: (early stage)
  • OpenGym:
  • Boston Patent Law Assn:

Nikhil Patel

New York, United States

Investing In

IT (& TMT) • Education • Businesses Solutions • FinTech (& Financials services) • Hardware (& Manufacturing) • Energy • Entertainment (& Sports) • HealthTech (& Fitness) • Logistics (& Distribution) • Material Science

Description

Experienced 10+ years Patent Attorney and Entreprenuer

Experienced 10+ years Patent Attorney and Entreprenuer

Kent Madsen
Investing in Software (Web Marketplace Saas..) &b...
 Salt Lake City, Utah, United States
Investor Picture
Previous Investments
  • Recursion Pharmaceuticals: $60000000 (Later stage VC)
  • Collective Medical Technologies: $47500000 (Early stage VC)
  • VNDLY: $35000000 (Later stage VC)
  • Conversa: $20000000 (Later stage VC)
  • SyncHR, Inc.: $16000000 (Later stage VC)
  • Numetric: $13000000 (Later stage VC)
  • RiskSense: $12000000 (Later stage VC)
  • Simplus: $9300000 (Later stage VC)
  • MagicCube, Inc.: $8500000 (Early stage VC)
  • Conversa Health: $8000000 (Early stage VC)
  • Marketware: $4500000 (Later stage VC)
  • Nevados: $3000000 (Later stage VC)
  • Spiff Inc: (mid stage)
  • PillPack: (mid stage)
  • WiZR: (early stage)
  • Health Catalyst: (late stage)
  • NUVI:
  • SilverVue: (mid stage)
  • Zenefits: (early stage)
  • Canopy, Inc.: (early stage)
  • Mountain West Capital Network:
  • Zuma Ventures: (early stage)
  • Knōd: (early stage)
  • Shape Security: (early stage)
  • HG Data: (early stage)
  • Janrain, Inc.:
  • Revit:
  • Everspin Technologies: (early stage)
  • ZettaCore, Inc (acquired by Atotech): (late stage)
  • Infinera: (mid stage)
  • Pivot, Inc., A CME Group Company (acquired by CME):
  • DivX, Inc. (nasdaq: DivX): (early stage)
  • LeftHand Networks:
  • Zions SBIC:
  • Linux Networx (Acquired by Silicon Graphics):
  • EPIC Venture Fund: (mid stage)
  • Netcentives (Nasdaq: NCNT):

Kent Madsen

Salt Lake City, Utah, United States

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • BioTech • Businesses Solutions • Hardware (& Manufacturing) • Energy • HealthTech (& Fitness) • Web Security (& Privacy) • Material Science • Investment Management

Description

Managing Director at EPIC Venture Fund

Managing Director at EPIC Venture Fund

Doug Sills
Investing in Media • BioTech • Business...
 Los Angeles - California, U.S.A.
Investor Picture
Previous Investments
  • Rollick: $8270000 (Early stage VC)
  • Darvis:

Doug Sills

Los Angeles - California, U.S.A.

Investing In

Media • BioTech • Businesses Solutions • FinTech (& Financials services) • Blockchain (& Cryptos) • Web Security (& Privacy) • Cloud Services (& Infrastructure) • Material Science • Payments • Pharmaceutical (& Medicine)

Alex Luce
Investing in BioTech • Hardware (& Manufactu...
 LatAm (Latin ) , San ..., U.S.A. - Canada
Investor Picture
Previous Investments
  • Picnic (Food Technology): $5000000 (Early stage VC)
  • AirWorks: $1260000 (Seed Round)
  • IOTAS, Inc.: $1000000 (Seed Round)
  • Sales Bootcamp: $600000 (Seed Round)
  • Lioness: (Early stage VC)
  • Relectrify: $9000000 (Series A)
  • OncoPrecision: $3000000 (Seed)
  • Oncoustics AI: $5000000 (Seed)
  • VenoStent: $3000000 (Seed)
  • Terra CO2: $9000000 (Seed)
  • Terra CO2 Technologies: (Seed)
  • Sepion: $2000000 (Seed)
  • Fort Robotics: (Seed)
  • Sepion Technologies: (Seed)
  • Visolis: $3400000 (Seed)

Alex Luce

LatAm (Latin ) - San Francisco Bay Area, U.S.A. - Canada

Investing In

BioTech • Hardware (& Manufacturing) • Energy • CleanTech • Food & Beverage • Material Science • Robotics • DeepTech • Mobility • Woman Focused

Description

Empowering Science Driven Founders

Ian Rountree
Investing in Software (Web Marketplace Saas..) &b...
 San Francisco Bay Are..., U.S.A.
Investor Picture
Previous Investments
  • Ava (Application):
  • Mako Aerospace: $700000 (Pre Seed Round)
  • Venus Aerospace: $20000000 (Series A)
  • Venus Aerospace: (Seed Round)
  • Venus Aerospace: $3200000 (Seed Round)
  • Radiant: $13000000 (Series A)
  • Atomos Space: $5000000 (Venture Round)
  • Sixfold Bioscience: $2200000 (Seed Round)
  • Debut: $23000000 (Series A)
  • Debut: $2600000 (Seed Round)
  • Phenomic AI: $6000000 (Seed Round)
  • Phenomic AI: $2000000 (Seed Round)
  • Circularis Biotechnologies: (Seed Round)
  • Character Biosciences: $6000000 (Seed Round)
  • Eridan: $8000000 (Series A)
  • Lively: $4200000 (Seed Round)
  • Rental Beast: $5000000 (Venture Round)
  • EasyPost: $4000000 (Seed Round)
  • EasyPost: $1200000 (Seed Round)
  • Public.com: $15000000 (Series B)
  • Clover Therapeutics: $3600000 (Seed)
  • Astranis: $40000000 (Series B)
  • Debut Biotechnology: (Seed)
  • Eridan Communications, Inc.: $7500000 (Series A)
  • Pow.bio: $1500000 (Pre-Seed)
  • XGenomes: $3000000 (Seed)
  • Concha Labs: $500000 (Pre-Seed)
  • Humane: $9000000 (Seed)
  • Chameleon Biosciences: $3000000 (Seed)
  • Phenomic: (Seed)
  • Mission Barns: $3500000 (Seed)
  • Atom Computing: (Seed)
  • Skyryse: $15000000 (Series A)
  • Vence: $1600000 (Pre-Seed)
  • Clara Health: $3000000 (Seed)
  • Opus 12: $2800000 (Pre-Seed)
  • Knowde: $1500000 (Pre-Seed)
  • Helium Health: $2500000 (Seed)
  • Visolis: $3400000 (Seed)
  • Qwil: $1600000 (Seed)
  • ADVANO: $4500000 (Seed)
  • Catalog Technologies: $5000000 (Seed)
  • Arable: $3000000 (Seed)
  • Anagram, Inc.: $3500000 (Seed)
  • Ethic: $1400000 (Pre-Seed)
  • ALICE Technologies: (seed)
  • Superhuman: (Series B)

Ian Rountree

San Francisco Bay Area - California, U.S.A.

Investing In

Software (Web Marketplace Saas..) • BioTech • Hardware (& Manufacturing) • Energy • Sales (& Marketing) • CleanTech • Impact • Material Science • Robotics • Aerospace (& Defense) • Woman Focused

Description

Views best described as cosmopolitan-cum-extropian

Most Interested In

Where the intersection of software, hardware, & wetware can create value in over a billion lives this decade––esp. industrial bio, aerospace, industrial robotics, next-gen computing hardware, and drug development.

Not Interested In

CPG, mobile-first, ad/marketing/sales, hiring-tech, anything that could have been built more than 2-3 years ago. Nor cannabis, therapeutics, or medical devices.


Most Interested In

Where the intersection of software, hardware, & wetware can create value in over a billion lives this decade––esp. industrial bio, industrial robotics, next-gen computing hardware, and drug development.

Not Interested In

CPG, mobile-first, ad/marketing/sales, hiring-tech, anything that could have been built more than 2-3 years ago. Nor cannabis, therapeutics, or medical devices.


Ian Rountree is the Founder of Cantos Ventures. He is an Agent and Chief of Staff at Invisible Technologies.

Jon Callaghan
Investing in Software (Web Marketplace Saas..) &b...
 San Francisco Bay Are..., U.S.A.
Investor Picture
Previous Investments
  • Automattic: $380690000 (Later stage VC)
  • Zymergen: $300000000 (Later stage VC)
  • Duo Security: $70000000 (Later stage VC)
  • Fractyl Laboratories: $44000000 (Later stage VC)
  • HashiCorp: $40000000 (Later stage VC)
  • Hodinkee: $40000000 (Later stage VC)
  • Splice: $35000000 (Later stage VC)
  • Nexar: $30000000 (Later stage VC)
  • Madison Reed, Inc.: $25000000 (Later stage VC)
  • Seurat Technologies, Inc.: $13500000 (Early stage VC)
  • Solvvy: $12000000 (Early stage VC)
  • Bigscreen: $11000000 (Early stage VC)
  • Bear Flag Robotics: $7900000 (Early stage VC)
  • Baffle: $6000000 (Early stage VC)
  • Allume: $3000000 (Seed Round)
  • OutboundWorks: $2250000 (Seed Round)
  • Diligent Robotics: $2100000 (Seed Round)
  • Mode:
  • Rise Science: $5500000 (Seed Round)
  • Ernesta: $25000000 (Series A)
  • Aisera: $90000000 (Series D)
  • Aisera: $40000000 (Series C)
  • Aisera: $20000000 (Series B)
  • MycoMedica Life Sciences, PBC: $60000000 (Series A)
  • Pipedream: $20000000 (Series A)
  • Wisq: $20000000 (Series A)
  • Wisq: $20000000 (Seed)
  • NoRedInk: $50000000 (Series B)
  • NoRedInk: $6000000 (Series A)
  • ClayStack: $5000000 (Seed)
  • Catch Co.: $38000000 (Series B)
  • Yousician: $28000000 (Series B)
  • Wefarm: $11000000 (Series A)
  • Wefarm: $13000000 (Series A)
  • Wefarm: $5000000 (Seed)
  • Health Gorilla: $15000000 (Series B)
  • Health Gorilla: $2000000 (Series A)
  • Health Gorilla: $2000000 (Seed)
  • Podhero: $4000000 (Seed)
  • Podhero: $3000000 (Seed)
  • Madison Reed: $61000000 (Series D)
  • Madison Reed: $16000000 (Series C)
  • Madison Reed: $12000000 (Series B)
  • Madison Reed: $4000000 (Series A)
  • Peloton: $550000000 (Series F)
  • Peloton: $330000000 (Series E)
  • Peloton: $30000000 (Series C)
  • MyVR: $6000000 (Series A)
  • 3D Robotics: $53000000 (Series D)
  • 3D Robotics: $50000000 (Series C)
  • 3D Robotics: $30000000 (Series B)
  • 3D Robotics: $5000000 (Series A)
  • littleBits Electronics: $47000000 (Series B)
  • littleBits Electronics: $11000000 (Series A)
  • littleBits Electronics: $4000000 (Series A)
  • Teachers Pay Teachers: $64000000 (Series Unknown)
  • Gigaom: $8000000 (Series F)
  • Gigaom: $6000000 (Series E)
  • Gigaom: $3000000 (Series D)
  • Gigaom: $5000000 (Series C)
  • Gigaom: $1000000 (Series B)
  • Gigaom: (Series A)
  • Handle Financial: $20000000 (Series E)
  • Handle Financial: $2000000 (Series Unknown)
  • Handle Financial: $12000000 (Series D)
  • Handle Financial: $16000000 (Series C)
  • Handle Financial: $3000000 (Series B)
  • Handle Financial: $3000000 (Series A)
  • Fitbit: $43000000 (Series D)
  • Fitbit: $12000000 (Series C)
  • Fitbit: $9000000 (Series B)
  • Fitbit: $2000000 (Series A)
  • BrightRoll: $20000000 (Series D)
  • BrightRoll: $10000000 (Series C)
  • BrightRoll: $5000000 (Series B)
  • BrightRoll: $1000000 (Series A)
  • Pose.com: $3000000 (Series A)
  • Pose.com: $2000000 (Series Unknown)
  • Bloomspot: $35000000 (Series B)
  • Bloomspot: $9000000 (Series A)
  • Bloomspot: $2000000 (Seed)
  • Ditto: $780000 (Seed)
  • Keep Holdings: $8000000 (Series A)
  • Milo: $4000000 (Series A)
  • 1000 Markets: $500000 (Seed)
  • Copan Systems: $19000000 (Series Unknown)
  • Copan Systems: $32000000 (Series D)
  • Three Rings: $1000000 (Convertible Note)
  • Three Rings: $4000000 (Series B)
  • ChessPark: $1000000 (Seed)
  • NextMedium: $6000000 (Series B)
  • NextMedium: $4000000 (Series A)
  • FilmLoop: $7000000 (Series B)
  • FilmLoop: $6000000 (Series A)
  • Meebo: $4000000 (Series A)
  • Meebo: $5000000 (Series Unknown)
  • Ingrian Networks: $15000000 (Series D)
  • Ingrian Networks: $14000000 (Series C)
  • KnowledgeFirst: $12000000 (Series B)

Jon Callaghan

San Francisco Bay Area - Palo Alto - California, U.S.A.

Investing In

Software (Web Marketplace Saas..) • BioTech • Businesses Solutions • Hardware (& Manufacturing) • IoT (& Wearables) • A.I. (& Big Data) • HealthTech (& Fitness) • Advertising • Material Science • Healthcare (& Wellness) • Consumer

Description

I am a very early stage venture capitalist and a Founder of True Ventures. I have started 3 companies as a Founder, and have been in the venture capital business since 1991. My background is mostly with early stage companies in the internet, media, mobile markets. My personal mission is to empower entrepreneurs because I believe that innovators can change the world. We started True Ventures because we felt as Founders that the traditional venture capital industry had grown too large to best serve the needs of the earliest stage entrepreneurs. At True, we have redesigned venture with the Founder as customer. Everything we do is designed to best help the early stage entrepreneur realize their dreams. We normally invest between $250,000-$2.5mm and are almost always the first investor in a company. Our deals are simple and clean and our funds are large for what we do. This means that although our initial checks are small, we are a powerful financial partner for a growing company, and we plan to invest large dollars with growth and success.I'm passionate about my kids, flying, and essentially anything outdoors. If we're meeting, be careful not to bring up airplanes, because I could spend all day talking about the wonder and beauty of flight, and we might not get much else done :).Specialties: very early stage venture capital, seed stage investing, startup advice, technology innovation, aviation

Adam Goobic
Investing in Software (Web Marketplace Saas..) &b...
 Michigan , Winter Par..., United States
Investor Picture
Previous Investments
  • Onapsis: $31000000 (Later stage VC)
  • Sparta Science: (mid stage)
  • Sayari Labs: (mid stage)
  • Stratifyd: (mid stage)

Adam Goobic

Michigan - Winter Park, Florida, United States

Investing In

Software (Web Marketplace Saas..) • IT (& TMT) • CleanTech • A.I. (& Big Data) • Material Science • Mobile

Description

Venture Investor

Venture Investor

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