Upfront Ventures

What is Upfront Ventures?

Upfront Ventures is a Venture Capital Fund headquartered at 1314 7th Street, Santa Monica, California, 90401, United States.

They manage $650 million in assets, focusing on equity investments in a diverse array of industries including Software, IT and TMT, Media, BioTech, AgroTech, Business Solutions, FinTech and Financial Services, Hardware and Manufacturing, Energy, Retail and E-Commerce, Sales and Marketing, Entertainment and Sports, CleanTech, A.I. and Big Data, Blockchain and Cryptos, Web Security and Privacy, Gaming and eSports, Advertising, Analytics, Cloud Services and Infrastructure, Developer Tools, Future Of Work, Human Resources, Insurance and InsurTech, Local Commerce, Logistics and Distribution, Medical Devices and Hospital Services, Payments, Aerospace and Defense, DeepTech, Healthcare and Wellness, Mobility, Nanotechnology, Online Social, Consumer, and Woman Focused sectors.

Upfront Ventures specializes in Seed, Startup, Early Stage, Expansion, Series A, and Series B investments, with a sweet spot for investment around $1,000,000, a minimum investment threshold of $750,000, and a maximum investment of $5,000,000.

Most interested in opportunities within Interactive Media including gaming, VR/AR, livestreaming, healthcare, AI, computer vision, IoT, and natural sciences, they leverage their expertise to support and grow companies that are at the forefront of technological and societal development.

Upfront Ventures strategically engages with enterprises that are poised to make significant impacts within their respective fields, aiming to foster innovation, drive progress, and yield substantial returns for their stakeholders.

What they say:

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

What we look for: We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

How we help: I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.