Main Sequence Ventures

About The Fund

Main Sequence Ventures is an early-stage venture capital fund based in Sydney, Australia, established in 2017 with the backing of CSIRO and the Australian federal government. Specializing in deep technology investments, Main Sequence Ventures targets ambitious entrepreneurs who are poised to create new market categories often originating from Australian public sector R&D. They actively seek to transform cutting-edge Australian research into globally influential companies, focusing on a diverse set of sectors such as security, energy and resources, enterprise software as a service (SaaS), farming and food, connected hardware, advanced materials, transportation and space, health, biology and genomics, AI and data science. With $450 million assets under management, their investments span early, seed, pre-seed, Series A, and Series B stages, with a minimum investment capacity of $250,000 and a maximum of $20,000,000, though their typical investment 'sweet spot' is approximately $10,100,000. Main Sequence Ventures employs a challenge-driven approach to investing, identifying global problems and their potential tech-driven solutions through categories they call 'Challenges', such as bridging the gap to space, decarbonizing the planet, enabling the next technology leap, feeding 10 billion people, achieving humanity-scale healthcare, and supercharging industrial productivity. They boast their ability to scale industrial productivity and strive to back inventors in the pursuit of unreasonable achievements. This encompasses a wide array of pioneering industries, from logistics and distribution through to aerospace and defense, with particular attention on consumer needs, healthcare, wellness, and woman-focused initiatives.